The role of iron chelation activity of wheat grass juice in patients with myelodysplastic syndrome.


No.	Divisions/Titles for Abstract	Details
1	Abstract Title	The role of iron chelation activity of wheat grass juice in patients with myelodysplastic syndrome.
2	Abstract Source	Journal of Clinical Oncology 2009 27:15S, 7012-7012 .
3	Abstract Author(s)	S. Mukhopadhyay , J. Basak , M. Kar , S. Mandal , A. Mukhopadhyay.
4	Article Affiliation	Netaji Subhas Chandra Bose Cancer Research Institute, Kolkata, India; NRS Medical College, Kolkata, India; Central Institute for Research (Ayurveda), Kolkata, India.
5	Abstract	Background: A pilot study with wheat grass juice in major thalassaemia patients was done by a group of clinicians in IPGMR, Chandigarh, India. We performed a study of 200 patients of intermediate thalassaemia with wheat grass juice and found 80% patients becoming transfusion independent. During the study in majority of the patients, serum ferritin level was significantly less as compared to pretreatment values. The aim of our study was to see the effect of wheat grass juice in reducing Ferritin level in myelodysplastic syndrome and also do the biochemical analysis of the wheat grass juice. Methods: During period from January 2003 to December 2007 we selected 20 patients of transfusion dependent myelodysplastic syndrome in the oncology department of Netaji Subhash Chandra Bose Cancer Research Institute. The age range of the patients was 42 years to 72 years (median 55 years). The fresh leaves of 5–7-day-old wheat grasss including stems were made fresh juice and had given 30 mL of juice daily to all 20 patients for continuous 6 months. Wheat grass juice was analyzed by column chromatography and found to be rich in oxalic and malic acid which might have some role in dietary absorption of iron from intestine. Beside that the wheat grass juice was found to contain two unique active ingredients with iron chelating property which was performed by deoxyribose degradation assay. We compared aqueous soluble extract of 5–7-day-old plant and dose-dependent study showed a significant iron chelating activity of crude extract in comparison to known standard iron chelator desferroxamine (DFO). The active compounds of crude extract of wheat grass may chelate catalytic iron in iron overload disorders when taking systematic dose. Result: The mean serum Ferritin level of the patients was 2,250 (range 650–4,800) before wheat grass treatment. The mean reduced to 950 (range 68–1680) (p < 0.0001). The performance status was improved from 60% to 80% (Karnofsky) after wheat grass treatment. The mean interval between transfusions was found increased. Conclusions: Wheat grass juice is an effective iron chelator and its use in reducing serum ferritin should be encouraged in myelodysplastic syndrome and other diseases where repeated blood transfusion is required.
6	Summary	Wheat grass juice is an effective iron chelator and its use in reducing serum ferritin should be encouraged in myelodysplastic syndrome and other diseases where repeated blood transfusion is required.
7	Article Published Date	May 1 ,2009.
8	Study Type	Clinical.
9	Substances	Wheat grass.
10	Diseases	myelodysplastic syndrome.
11	Pharmacological Actions	chelating agent.
12	Link	https://goo.gl/KCPkzf