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Synergistic lipid-lowering effects of alfalfa meal as an adjuvant to the partial ileal bypass operation.

Synergistic lipid-lowering effects of alfalfa meal as an adjuvant to the partial ileal bypass operation.









No. Divisions/Titles for Abstract Details

1 Abstract Title Synergistic lipid-lowering effects of alfalfa meal as an adjuvant to the partial ileal bypass operation.


2 Abstract Source Surgery, 102, 39-51.


3 Abstract Author(s) Esper, E., Barichello, A. W., Chan, E. K., Matts, J. P. & Buchwald, H.


4 Article Affiliation Department of Surgery, University of Minnesota, Minneapolis, Minn., USA.

5 Abstract Partial ileal bypass (PIB) (Partial ileal bypass surgery is a surgical procedure which involves shortening the ileum to shorten the total small intestinal length)and ingestion of alfalfa (Alfalfa(Medicago sativa)also called Lucerne, is naturally high in many essential vitamins and minerals, including A, D, E, K, and even the full family of B vitamins; biotin, calcium, folic acid, iron, magnesium, potassium and many others, as well as being very high in protein, especially when dried. It is "The king of all foods"!)are both known to lower plasma cholesterol ( a waxy, fat-like substance that occurs naturally in all parts of the body. Your body needs some cholesterol to work properly) levels. During an 18-week period, the combined effects of both were studied in four randomized groups of rabbits receiving C-free, hypercholesterolemia-(also called high cholesterol, is the presence of high levels of cholesterol in the blood. It is a form of high blood lipids and hyperlipoproteinemia (elevated levels of lipoproteins in the blood) inducing, semisynthetic diets 3 weeks after sham or PIB surgery. The diets, with or without alfalfa, had similar overall compositions of fat, protein, carbohydrate, and fiber. We measured blood C, triglycerides (T), and lipoprotein (a biochemical assembly that contains both proteins and lipids , bound to the proteins , which allow fats to move through the water inside and outside cells)fractions of both C and T at biweekly intervals. In vivo liver and small-bowel synthesis of C, fatty acids (FA), and nonsaponifiable lipids (NSL) were determined with radioactive 14C-acetate at the end of the study. The results were evaluated by means of analysis of variance using unweighted cell means. The combined PIB and alfalfa modalities significantly lower C levels in serum, plasma, low-density lipoproteins, and high-density lipoproteins by 66%, 71%, 85%, and 35%, respectively. However, due to alfalfa, a significant increase of 49% was observed in plasma T when both treatments were combined. Liver FA synthesis was significantly decreased (65%) with PIB and increased (161%) with alfalfa; when the two treatments are combined, a nonsignificant response was observed. Similarly, this inverse relationship for PIB and alfalfa was seen for C and NSL synthesis. Small-bowel FA synthesis was significantly decreased (72%) by the combination of PIB and alfalfa. We conclude that alfalfa suppresses, in part, the physiologic rebound effect of PIB surgery by increasing hepatic C and NSL synthesis; inversely, PIB surgery inhibits the additive effect in the liver synthesis of FA produced by alfalfa. Alfalfa and PIB alone, and synergistically (relating to the interaction or cooperation of two or more organizations, substances, or other agents to produce a combined effect greater than the sum of their separate effects), decrease total small-bowel lipid synthesis, specifically that of FA. Alfalfa is an effective adjuvant to PIB for reducing total and lipoprotein C fractions.


6 Summary Alfalfa and PIB alone, and synergistically, decrease total small-bowel lipid synthesis, specifically that of FA. Alfalfa is an effective adjuvant to PIB for reducing total and lipoprotein C fractions.


7 Article Published Date Jul-1987.


8 Study Type invivo.


9 Substances Alfalfa.


10 Diseases Hypercholesterimia.


11 Pharmacological Actions hypocholesterimia.


12 Link https://goo.gl/qABgPW








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