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Potential Anticancer Properties of Grape Antioxidants.

Potential Anticancer Properties of Grape Antioxidants.










No.Divisions/Titles for AbstractDetails

1Abstract TitlePotential Anticancer Properties of Grape Antioxidants.


2Abstract SourceJ Oncol, 803294, 7.


3Abstract Author(s)Zhou, K. & Raffoul, J. J.


4Article Affiliation
Department of Nutrition and Food Science, Wayne State University, Detroit, MI 48202, USA.


5AbstractDietary intake of foods rich in antioxidant properties is suggested to be cancer protective. Foods rich in antioxidant properties include grape (Vitis vinifera), one of the world’s largest fruit crops and most commonly consumed fruits in the world. The composition and cancer-protective effects of major phenolic antioxidants in grape skin and seed extracts are discussed in this review. Grape skin and seed extracts exert strong free radical scavenging and chelating activities and inhibit lipid oxidation in various food and cell models in vitro. The use of grape antioxidants are promising against a broad range of cancer cells by targeting epidermal growth factor receptor (EGFR) and its downstream pathways, inhibiting over-expression of COX-2 and prostaglandin E2 receptors, or modifying estrogen receptor pathways, resulting in cell cycle arrest and apoptosis. Interestingly, some of these activities were also demonstrated in animal models. However, in vivo studies have demonstrated inconsistent antioxidant efficacy. Nonetheless, a growing body of evidence from human clinical trials has demonstrated that consumption of grape, wine and grape juice exerts many health-promoting and possible anti-cancer effects. Thus, grape skin and seed extracts have great potential in cancer prevention and further investigation into this exciting field is warranted.


6Summarygrape skin and seed extracts have great potential in cancer prevention.


7Article Published Date2012.

8Study TypeReview.

9SubstancesGrape skin.

10DiseasesCancer.

11Pharmacological Actionsanti-cancer,antioxidant.


12Linkhttps://goo.gl/y3Y7Bn








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