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Effects of Nigella sativa oil extract on inflammatory cytokine response and oxidative stress status in patients with rheumatoid arthritis.

Effects of Nigella sativa oil extract on inflammatory cytokine response and oxidative stress status in patients with rheumatoid arthritis.










No.Divisions/Titles for AbstractDetails

1Abstract TitleEffects of Nigella sativa oil extract on inflammatory cytokine response and oxidative stress status in patients with rheumatoid arthritis: a randomized, double-blind, placebo-controlled clinical trial.


2Abstract SourceAvicenna J Phytomed, 6, 34-43.


3Abstract Author(s)Hadi, V., Kheirouri, S., Alizadeh, M., Khabbazi, A. & Hosseini, H.


4Article Affiliation

1 Department of Nutrition, Tabriz University of Medical Sciences, Tabriz, Iran.

2 Department of Internal Medicine, Tabriz University of Medical Sciences, Tabriz, Iran.

3 Department of Agriculture, Barij Essence Pharmaceutical Company , Kashan, Iran.



5Abstract

OBJECTIVE:

Nigella sativa is a medicinal plant that has long been used in traditional medicine for treating various conditions. Numerous animal studies provided evidences that the seed may elicit a broad anti-inflammatory/anti-oxidant activity. The aim of the present clinical trial was to evaluate anti-inflammatory and antioxidant properties of Nigella sativa oil in patients with rheumatoid arthritis (RA).

MATERIALS AND METHODS:

Forty-two patients with RA were assigned into two groups in this randomized, double blind, placebo-controlled clinical trial. Subjects in intervention group received two capsules, 500 mg each, of Nigella sativa oil, each day for 8 weeks. The other group consumed two capsules as placebo per day for the same period of time. Serum TNF-α, IL-10, and whole blood levels of oxidative stress parameters were measured at baseline and end of the trial.

RESULTS:

The serum level of IL-10 was increased in the Nigella sativa group (p<0.01). Moreover, treatment with Nigella sativa led to significant reduction of serum MDA and NO compared with baseline (p<0.05). There were no significant differences in the TNF-α, SOD, catalase, and TAS values between or within the groups, before and after the intervention (p>0.05).

CONCLUSION:

This study indicates that Nigella sativa could improve inflammation and reduce oxidative stress in patients with RA. It is suggested that Nigella sativa may be a beneficial adjunct therapy in this population of patients.



6Summary-

7Article Published Date2016.

8Study TypeA randomized, double-blind, placebo-controlled clinical trial.


9SubstancesBlack Cumin.

10DiseasesArthritis.

11Pharmacological ActionsNigella sativa could improve inflammation and reduce oxidative stress in patients with RA.


12Linkhttps://goo.gl/AinJum








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