Dietary Supplementation of Grape Skin Extract Improves Glycemia and Inflammation in Diet-Induced Obese Mice Fed a Western High Fat Diet.


No.	Divisions/Titles for Abstract	Details
1	Abstract Title	Dietary Supplementation of Grape Skin Extract Improves Glycemia and Inflammation in Diet-Induced Obese Mice Fed a Western High Fat Diet.
2	Abstract Source	Journal of agricultural and food chemistry, 59, 3035-3041.
3	Abstract Author(s)	Hogan, S., Canning, C., Sun, S., Sun, X., Kadouh, H. & Zhou, K.
4	Article Affiliation	† Department of Food Science and Technology, Virginia Polytechnic Institute and State University, Blacksburg, Virginia 24061, United States § Department of Nutrition and Food Science, Wayne State University, Detroit, Michigan 48202, United States ‡ Montana State University, Bozeman, Montana 59717.
5	Abstract	Dietary antioxidants may provide a cost-effective strategy to promote health in obesity by targeting oxidative stress and inflammation. We recently found that the antioxidant-rich grape skin extract (GSE) also exerts a novel anti-hyperglycemic activity. This study investigated whether 3-month GSE supplementation can improve oxidative stress, inflammation, and hyperglycemia associated with a Western diet-induced obesity. Young diet-induced obese (DIO) mice were randomly divided to three treatment groups (n = 12): a standard diet (S group), a Western high fat diet (W group), and the Western diet plus GSE (2.4 g GSE/kg diet, WGSE group). By week 12, DIO mice in the WGSE group gained significantly more weight (24.6 g) than the W (20.2 g) and S groups (11.2 g); the high fat diet groups gained 80% more weight than the standard diet group. Eight of 12 mice in the W group, compared to only 1 of 12 mice in the WGSE group, had fasting blood glucose levels above 140 mg/dL. Mice in the WGSE group also had 21% lower fasting blood glucose and 17.1% lower C-reactive protein levels than mice in the W group (P < 0.05). However, the GSE supplementation did not affect oxidative stress in diet-induced obesity as determined by plasma oxygen radical absorbance capacity, glutathione peroxidase, and liver lipid peroxidation. Collectively, the results indicated a beneficial role of GSE supplementation for improving glycemic control and inflammation in diet-induced obesity.
6	Summary	the results of this study indicated a beneficial role of GSE supplementation for improving glycemic control and inflammation in diet-induced obesity.
7	Article Published Date	2011.
8	Study Type	Invivo.
9	Substances	Grape skin.
10	Diseases	inflammation , oxidative stress.
11	Pharmacological Actions	anti-hyperglycemic , antiinflammatory , antioxidant.
12	Link	https://goo.gl/trJ4XW