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Carnosic acid, a new class of lipid absorption inhibitor from sage.

Carnosic acid, a new class of lipid absorption inhibitor from sage.

No.Divisions/Titles for AbstractDetails

1Abstract TitleCarnosic acid, a new class of lipid absorption inhibitor from sage.

2Abstract Source Bioorg Med Chem Lett, 14, 1943-6.

3Abstract Author(s)Ninomiya, K., Matsuda, H., Shimoda, H., Nishida, N., Kasajima, N., Yoshino, T., Morikawa, T. & Yoshikawa, M.

4Article AffiliationKyoto Pharmaceutical University, Misasagi, Yamashina-ku, Kyoto 607-8412, Japan.

5AbstractThe methanolic extract from the leaves of Salvia officinalis L. (sage) showed significant inhibitory effect on serum triglyceride elevation in olive oil-loaded mice (500 and 1000 mg/kg, p.o.) and inhibitory activity (IC(50): 94 microg/mL) against pancreatic lipase, which is participated in digestion of lipids. Through bioassay-guided separation using the inhibitory activity against pancreatic lipase activity, 4 abietan-type diterpenes (carnosic acid, carnosol, royleanonic acid, 7-methoxyrosmanol) and a triterpene (oleanolic acid) were isolated from the active fraction. Among these compounds, carnosic acid and carnosol substantially inhibited pancreatic lipase activity with IC(50) values of 12 microg/mL (36 microM) and 4.4 microg/mL (13 microM), respectively. Carnosic acid significantly inhibited triglyceride elevation in olive oil-loaded mice at doses of 5-20 mg/kg (p.o.). However, other constituents (carnosol, royleanonic acid, oleanolic acid) did not show any effects at a dose of 200 mg/kg (p.o.). Furthermore, carnosic acid (20 mg/kg/day, p.o.) reduced the gain of body weight and the accumulation of epididymal fat weight in high fat diet-fed mice after 14 days.


7Article Published Date2004.

8Study TypeInvitro.



11Pharmacological ActionsTreatment of Obesity.


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